Research - Pilot Projects

The Center Fosters Innovation

To achieve its stated goals and objective in an efficient and timely fashion, the Center must be responsive to new research opportunities, technological breakthroughs and the changing needs of its varied constituencies. 

The principal mechanism for achieving this responsiveness and flexibility is through the Pilot Project Core. Under the direction of Professor Bruce Ames, and in consultation with the Center's Executive Committee, a number of pilot projects are funded each year.  Unlike the principal research project of Center investigators, pilot projects are high risk, exploratory research projects with the potential to advance the Center's research, education, training and outreach goals in significant and unanticipated ways. Provided below are pilot projects (funded and unfunded) for 2005, 2006 and 2007.  Pilot projects are listed alphabetically by the principle investigator's last name.

2007 Pilot Projects

  • Effect of Dietary Intervention with a Micronutrient and Fiber Supplement on Inflammation and Insulin Resistance in Childhood Obesity: B. Ames and A. Lal, Co- Principal Investigators.

  • Pool-based genotyping of Af. Am. Samples for the PARC Study: K. Beckman, Principal Investigator.

  • Upregulation of UGT1A1 and its effect on PhIP-induced prostate cancer: A. Galvez, Principal Investigator.

  • Decrease of cellular zinc promotes prostate cancer development: L. Huang, Principal Investigator.

  • Genetic Susceptibility to Obesity-Related Dyslipidemia in African Americans: R. Krauss, Principal Investigator.

  • Advanced Biocomputation using 64-bit architectures Enhanced with High-Performance FPGA Accelerators: W. Malyj and K. Dawson, Co- Principal Investigators.

  • Effect of diet on reproductive performance and placental expression of genes involved in the inflammatory response: J. Noble, Principal Investigator.

  • Diabetes Prevention in a Southeast Asian Population: B. Staggers and P. Wakimoto, Co- Principal Investigators.

  • Assessing the Contribution of Individual Sun Exposure to Vitamin D Status: C. Stephensen and J. King, Co- Principal Investigators.

 

2006 Pilot Projects

  • Gene Expression changes during oncogenic transformation of normal prostate cells in response to treatment with a chemopreventive soy peptide: A. Galvez, Principal Investigator.

  • Regulation by Selenium of Genetic Pathways Leading to Prostate Cancer:  C. Hawks, Principal Investigator, K Dawson and R. deVere White, members.

  • Prostate Zinc Homeostasis and Prostate Carcinogenesis: L. Huang, Principal Investigator.

  • Laboratory for Nutrigenomic Medicine - Translational Research on Type 2 Diabetes: J. Kaput, Principal Investigator, K. Beckman, J. Noble, K. Dawson, W. Malyj, A. Bartholomew (University of Illinois Chicago), B. Hatipoglu (UIC), K. Kohrs (UIC), A. Masud (UIC), F. Gilet (UIC), member.

  • NUGAT - Nutritional Genomics of Adipose Tissue: R. Krauss, Principal Investigator, L. Mangranvite, member.

  • Non-Linear Algorithms in Bioinformatics - Dimensionality Reduction of Large, Complex and Noisy Datasets: W. Malyj, Principal Investigator, K. Dawson, member.

  • Placental genetics, inflammatory markers and pregnancy outcomes among minority women: R. Mukherjea, Principal Investigator, J. King, M. Shigenaga, K. Beckman, C. Kunz and C. Stephensen, members.

  • Surveying the impact of acute and chronic micronutrient deficiency on bacterial/lipopolysaccharide invasion and inflammation in visceral fat: M. Shigenaga, Principal Investigator.

  • Effects of Vitamin D Supplements on Immune Function, Bone Turnover and Strength: C. Stephensen, Principal Investigator, P. Armstrong, member.

  • The metabolic status of biotin during pregnancy in four ethnic groups: M. Shigenaga, Principal Investigator.

  • Community-Based Participatory Research-Cross Cultural Strategies for Obesity Prevention: P. Wakimoto, Principal Investigator, M. Tervalon and B. Staggers, members.

 

2005 Pilot Projects

  • The Metabolic Status of Biotin During Pregnancy in Four Ethnic Groups:  H. Atamna Principal Investigator, M. Shigenaga, Hal Helbock, members.

  • Regulation by Selenium of Genetic Pathways Leading to Prostate Cancer: C. Hawkes Principal Investigator, P.-J. Chang, member.

  • Prostate Zinc Homeostasis and Prostate Carcinogenesis: L. Huang, Principal Investigator.

  • Gene Panels for Identifying Type-2 Diabetes: J. Kaput, Principal Investigator, K. Dawson, W. Malyj, A. Bartholomew, members.

  • NUGAT - Nutritional Genomics of Adipose Tissue: R. Krauss, Principal Investigator, L. Mangravite, member.

  • Non-Linear Algorithms in Bioinformatics - Dimensionality Reduction of Large, Complex and Noisy Datasets: W. Malyj, Principal Investigator, K. Dawson, member.

  • HLA Polymorphism and Genetic Disparities Between Blacks and Whites: J. Noble, Principal Investigator.

  • Elucidations of the Molecular Mechanism Underlying the Chemopreventive Nature of a Soybean Peptide.  R. L. Rodriguez, Principal Investigator, F. Galvez, member.

  • Surveying the Impact of Acute and Chronic Micronutrient deficiency on Bacterial/Lipopolysaccharide Invasion and Inflammation in Visceral Fat: M. Shigenaga, Principal Investigator, H. Atamna, member.